Introduction
A jacketed glass reactor is a laboratory reactor with a double-walled glass vessel, in which the space between the walls is used for the circulation of the heating or the cooling fluid, and it is used in the chemistry, the pharmaceutical, the chemical engineering, and the research laboratories for the reactions under the controlled temperature. The jacketed glass reactor consists of a glass vessel with an inner layer and an outer jacket, a circulation system for the heating or the cooling fluid, such as the water or the oil, a stirring system, a reflux condenser, and the inlets and the outlets for the addition and the sampling, and it provides the controlled temperature of the reaction by the circulation of the fluid through the jacket, with a high uniformity and a precise control, with features such as the adjustable stirring speed, the temperature control, and the vacuum connection; the jacketed glass reactor is used for the chemical synthesis, for the reactions at the controlled temperature, for the exothermic and the endothermic reactions, for the distillation and the reflux, for the crystallization, for the reactions under the vacuum, and for many other applications, and it is available in various capacities, from the small laboratory models to the larger models, with the various stirring and the heating configurations; the jacketed glass reactor is an essential instrument for the temperature-controlled reactions in the laboratory. Jacketed glass reactors are used in the chemistry laboratories, in the pharmaceutical industry, in the chemical engineering, in the research institutions, and for many other applications. With their temperature control, jacketed glass reactors are essential for the controlled reactions.
Jacketed Glass Reactor LJGR-T2019
Jacketed Glass Reactor features a durable 2 L cylindrical vessel for controlled synthesis and distillation. Its dropping funnel enables gradual reagent addition during complex experiment...
Jacketed Glass Reactor LJGR-T2018
Jacketed Glass Reactor features a 1 reactions in research and industrial applications. This laboratory glass reactor is designed to meet the rigorous requirements of modern laboratory op...
Jacketed Glass Reactor LJGR-T2017
Jacketed Glass Reactor features a 5 jacket circulates thermal fluids to maintain stable temperatures. The reinforced glass lid ensures secure sealing during complex reactions and maintai...
Jacketed Glass Reactor LJGR-T2016
Jacketed Glass Reactor features a 3 stirring shaft withstands harsh solvents and supports long-term use. Our Jacketed Glass Reactor is suitable for synthesis, distillation, and material ...
Jacketed Glass Reactor LJGR-T2015
Jacketed Glass Reactor features a 2 chemical processes. The stable frame design provides firm support, reducing vibrations during high-speed stirring. Its circulation jacket ensures stea...
Jacketed Glass Reactor LJGR-T2014
Jacketed Glass Reactor features a 1 L cylindrical glass vessel allowing easy access for material addition and setup adjustments. The external condenser supports vapor cooling during refl...
Jacketed Glass Reactor LJGR-T2013
Jacketed has a 5 processes. The unit supports a wide temperature range, enabling use in thermally demanding applications. Our Glass Reactor is ideal for research involving synthesis, dis...
Jacketed Glass Reactor LJGR-T2012
Jacketed Glass Reactor has a 3 for chemical reactions requiring controlled temperature variation. It ensures stable performance during extended use, supporting complex, multi-step proces...
Jacketed Glass Reactor LJGR-T2011
Jacketed Glass Reactor has a 2 jacket. The stirring speed range accommodates different viscosities for various reaction types. Its wide temperature range allows flexible use across many ...
Jacketed Glass Reactor LJGR-T2010
Jacketed Glass Reactor features a 1 L cylindrical glass vessel that ensures chemical compatibility while withstanding thermal fluctuations. The fixed external loop buffer enables continu...
Standards
ISO 3585:1998-Borosilicate glass 3.3-Properties
Complies with the above standards, but is not limited to them.
Features
1. Jacketed glass reactor for controlled chemical synthesis with heating/cooling circulation through glass jacket.
2. Double-walled glass vessel with overhead stirrer, reflux condenser, addition funnel, and temperature control.
3. Suitable for chemical, pharmaceutical, biotech, food, cosmetic and research laboratories for synthesis and scale-up.
4. Includes glass vessel (jacketed), overhead stirrer, condenser, feed tank, temperature probe, stand and manual.
5. Supports batch reactions under vacuum/pressure, heating/cooling, distillation, reflux, extraction and crystallization.
FAQ
Q1: What testing scenarios is this reactor mainly applied to?
A: The jacketed glass reactor is used in chemical, pharmaceutical, biotechnology, food, cosmetic, and research laboratories for controlled chemical reactions, synthesis, and process scale-up, where the double-walled glass jacket allows circulation of heating or cooling fluid (oil/water) to precisely control reaction temperature, while the transparent glass allows visual monitoring of the reaction. It supports chemical synthesis (organic synthesis, polymerization, condensation, oxidation, reduction, Grignard reactions, hydrolysis, esterification - controlled temperature, stirring, reagent addition under inert atmosphere), pharmaceutical (API (active pharmaceutical ingredient) synthesis and scale-up, crystallization, salt formation, solvent recovery, process development (lab to pilot scale), cGMP production), biotechnology (cell culture (if suitable), fermentation, enzyme reactions, protein precipitation, bioconversion), food and beverage (flavor extraction, essential oil distillation, reaction of food-grade ingredients, crystallization of sugars/sweeteners), cosmetic and personal care (emulsion preparation, cream/lotion synthesis, fragrance extraction, surfactant reactions), chemical process development (optimization of reaction parameters (temp, time, stoichiometry, stirring speed), scale-up from lab (1-5 L) to pilot (10-100 L), kinetic studies), and academic/research (teaching, research, method development). The jacketed design: inner vessel holds reaction mixture; outer jacket circulates heat transfer fluid (thermal oil for heating to 200-250 degrees C, or coolant/ethylene glycol for cooling to -20 to -80 degrees C with chiller). This allows precise temperature control (often +/- 0.5 degrees C) and rapid heating/cooling. Glass (borosilicate 3.3) is chemically resistant and transparent, allowing visual inspection. Typically operates at atmospheric pressure or mild vacuum (for distillation/degassing); some models handle slight positive pressure. Overhead stirrer provides mixing (anchor, paddle, or PTFE stirrer). Accessories: reflux condenser (for volatile solvents), addition funnel (controlled reagent addition), thermometer/thermowell, vacuum port, inert gas (N2/Ar) inlet, discharge valve at bottom.
Q2: What standards does the reactor comply with?
A: The jacketed glass reactor follows relevant ISO, ASTM, IEC, FDA and GB/T standards including ISO 1778 (laboratory glassware - general purpose), ISO 3585 (borosilicate glass 3.3 - properties), ISO 4793 (laboratory sintered glass filters), ASTM E438 (standard specification for glasses in laboratory apparatus - type I class A (borosilicate)), IEC 61010 (laboratory electrical equipment safety - for stirrer/temperature controller), FDA 21 CFR (if pharmaceutical/food contact - glass is generally recognized as safe (GRAS) for food/pharma), and GB/T standards for glass reactors and laboratory glassware. The hardware complies with pressure/vacuum ratings (glass vessels have specific pressure limits - typically full vacuum to slight positive pressure; do not exceed manufacturer rating), glass quality (borosilicate 3.3 per ISO 3585/ASTM E438), and electrical safety (stirrer, temperature controller per IEC 61010). For pharmaceutical use, follow cGMP (21 CFR Part 211), equipment qualification (IQ/OQ/PQ), and material traceability (glass certificates, stirrer material certificates (PTFE, stainless steel 316L)). For food use, follow FDA food contact regulations and applicable food-grade standards. For pressure operation, follow pressure vessel safety (though glass reactors are typically not for high pressure - use autoclave for pressure reactions). For solvent use, follow fire/explosion safety (flammable solvents require spark-free equipment, fume hood, inert atmosphere). For regulated industries, maintain calibration records (temperature probe, stirrer speed) and equipment logs.
Q3: What is the warranty period for the whole reactor and key components?
A: The whole jacketed glass reactor is covered by a 12-24 month warranty (lab equipment often 1-2 years; glass may have shorter warranty due to fragility). The stand, overhead stirrer motor, temperature controller, and metal fittings are covered, while glass vessel (wear/breakable - glass can crack from thermal shock, impact, overpressure; handle carefully; some warranty excludes glass breakage), seals/gaskets (PTFE, silicone - wear from chemical attack/heat, replace periodically), stirrer shaft/blade (wear, especially PTFE coating), and hoses (for jacket fluid - wear from heat/chemicals) are consumables/accessories. Damage from improper use, thermal shock (rapid temperature change - hot glass + cold coolant = crack; always heat/cool gradually), overpressure (exceeding glass pressure rating - can implode/explode), dropping/impact (glass is fragile), using incompatible chemicals (HF attacks glass; strong bases at high temp etch borosilicate), dry heating (no fluid in jacket while heating - cracks glass), or unauthorized repair is excluded. Extended warranty and service contracts (preventive maintenance, calibration) may be available. Glass vessel lifespan: 3-10 years with proper care (but can break anytime from misuse/accident); stirrer motor 5-10 years; seals 1-3 years.
Q4: Is this device difficult to operate? Is professional training required?
A: Operation requires trained chemistry/lab personnel (familiar with chemical reactions, glassware, hazardous materials, temperature control). We provide operation manuals, installation, and training (typically 1-3 days). Proper setup (place reactor on stable, level bench or floor stand (large reactors need floor stand), assemble glass components (vessel, lid, condenser, addition funnel, stirrer) using proper clamps and supports (glass must not be under stress - leave room for thermal expansion), connect jacket hoses to heating/circulator (inlet/outlet; ensure no air locks in jacket - bleed air), connect overhead stirrer (secure shaft, ensure blade does not touch vessel bottom/walls; adjust height), connect temperature probe (thermowell with heat transfer fluid or direct probe; ensure probe is in reaction mixture, not touching vessel), connect vacuum/inert gas (if needed), connect cooling water to condenser (if reflux/distillation), verify all connections are tight and clamps secure), pre-operation checks (inspect glass for cracks/stars (do not use cracked glass - can fail catastrophically), verify jacket fluid level in circulator, ensure stirrer rotates freely (no binding), check seals/gaskets for damage, ensure emergency stop accessible, have spill kit/eyewash nearby), operation (add reactants/solvent through top port or addition funnel (do not fill >2/3 of vessel volume - leave headspace for boiling/foaming), start stirrer (set speed - start low, increase gradually; avoid splashing), start jacket circulation (set temperature - heat/cool gradually to avoid thermal shock; monitor temperature), add reagents via addition funnel at controlled rate (for exothermic reactions, add slowly with cooling; monitor temp), maintain inert atmosphere (N2/Ar) if air/moisture sensitive, monitor reaction (visually through glass, via temperature, sampling (use sampling valve or syringe), TLC/HPLC), for distillation: set up condenser, receiver, vacuum; for reflux: condenser with coolant, post-operation (stop heating, allow cooling (gradual - do not shock with cold coolant while glass is hot), stop stirrer, release vacuum/inert gas carefully, discharge product via bottom valve (if equipped) or pour out, clean reactor (rinse with appropriate solvent, then water/detergent; remove glass components for thorough cleaning; do not use abrasive brushes on glass (scratches weaken glass); dry thoroughly), maintenance (daily: wipe exterior, check jacket fluid, inspect glass for damage, clean spills immediately; weekly: inspect seals/gaskets (replace if cracked/hardened), check stirrer shaft alignment, lubricate (per manufacturer); monthly: verify temperature probe calibration (with certified thermometer), check stirrer speed, inspect hoses for cracks/leaks; semi-annually/annually: professional maintenance (stirrer motor, controller calibration, pressure/vacuum test of glass vessel), troubleshooting (temperature not reaching setpoint (jacket fluid low, circulator failure, air lock in jacket, insulation poor, exothermic/endothermic reaction overwhelming capacity - check fluid, bleed air, increase circulator capacity), stirrer not rotating (motor failure, shaft binding (touching vessel), overload (viscous mixture - reduce speed, use appropriate blade), seal leak (PTFE/silicone seal worn/chemically attacked, over-tightened, misaligned - replace seal, adjust), glass crack/leak (thermal shock, impact, overpressure, chemical attack (HF, hot base) - STOP immediately, do not use cracked glass (can implode/explode under vacuum/pressure), replace vessel), jacket leak (hose loose/cracked, glass jacket cracked - check hoses, inspect jacket), pressure/vacuum not holding (seal leak, glass crack, fitting loose - check seals, glass, fittings), and safety (GLASS HAZARD (borosilicate glass can break/implode/explode - wear safety glasses/face shield, lab coat, gloves; do not use cracked glass; never exceed pressure/vacuum rating; use blast shield for pressure/vacuum reactions; beware of implosion under vacuum (flying glass)), CHEMICAL HAZARD (reactions may involve flammable, corrosive, toxic, reactive chemicals - use fume hood, appropriate PPE, know SDS, have spill kit/eyewash/shower; exothermic reactions can runaway - use cooling, controlled addition, never leave unattended; pyrophoric/air-sensitive materials require inert atmosphere and special handling), PRESSURE/VACUUM (glass reactors are typically for atmospheric or mild vacuum; do NOT pressurize unless rated; if pressure reaction needed, use metal autoclave; under vacuum, beware of implosion), THERMAL SHOCK (never add cold coolant to hot jacket or hot fluid to cold glass - heat/cool gradually; thermal shock is a major cause of glass breakage), OVERFILLING (do not fill >2/3 - boiling/foaming can overflow, cause pressure), STIRRER (do not start at high speed (splashing, shaft whip); ensure blade does not touch glass (scratches/cracks), do not run dry), ELECTRICAL (stirrer/controller - proper grounding, do not use with wet hands, keep away from solvent vapors (spark hazard)), do not leave reaction unattended (especially exothermic or distillation), for pharma/food: follow cGMP (cleaning validation, batch records, equipment logs), handle glass carefully (support all glass joints, do not stress, use proper clamps)) are critical for safe reactor operation.
Q5: What is the typical lead-time for order delivery?
A: Standard models require 7-30 working days. In-stock units can ship within 3-7 working days. Custom configurations or large built-to-order systems may require additional time, and we confirm the exact schedule before order confirmation.
Q6: Is regular calibration required? What is the recommended calibration cycle?
A: Calibration/performance verification recommended every 6-12 months (or per quality system): temperature probe calibration (with certified thermometer traceable to national standards; verify at multiple points across range (e.g., 0, 50, 100, 200 degrees C); accuracy typically +/- 0.5 degrees C), stirrer speed calibration (with tachometer; verify at low/mid/high speeds), and temperature uniformity (jacket vs vessel - verify with multiple probes). If reactor is moved, probe replaced, stirrer serviced, or readings seem off, recalibrate. Routine checks: temperature probe verification before critical reactions (compare with reference thermometer), stirrer speed check, glass inspection (cracks) before each use. For GMP/pharma labs, follow applicable calibration schedules and maintain records (calibration certificates, as-found/as-left data, probe ID, equipment logs). Glass vessel integrity: pressure/vacuum leak test annually or after any impact/repair. Heating/cooling circulator should be calibrated separately (per manufacturer). For pharma cGMP, equipment qualification (IQ/OQ/PQ) is required initially and re-qualification periodically (annually or after major repair).
Q7: Are supporting consumables universal?
A: Seals/gaskets (PTFE, silicone, Viton - specific to reactor joint size (standard ground glass joints: NS 24/40, 29/42, etc.; use appropriate size/material for chemical compatibility), stirrer shaft/blade (specific to reactor size/stirrer; PTFE or 316L), hoses (for jacket fluid - standard rubber/silicone, but use heat-resistant if high temp), glass components (condenser, addition funnel, adapters - standard ground glass joints are somewhat universal (ISO/ASTM joint sizes), but use manufacturer-compatible for proper fit), temperature probe (specific to controller), and cleaning supplies are available from lab supply companies (Chemglass, Ace Glass, VWR, Sigma), though seals and stirrers are often reactor-specific (use OEM or certified compatible with correct dimensions/materials). Long-term consumable cost includes seal/gasket replacement (periodic, $20-$100 per set), stirrer blade (if worn/broken), and occasional glass replacement (if broken - expensive, $500-$5000+ depending on size).
Q8: Can I customize parameters or supporting accessories?
A: Customization includes volume (1 L, 2 L, 5 L, 10 L, 20 L, 50 L, 100 L, 200 L - lab to pilot scale), vessel design (single jacket (heating/cooling), double jacket (insulation + temperature), triple jacket (for extreme temps), cylindrical or spherical bottom, bottom discharge valve), number/type of ports (4-neck, 6-neck lid; ports for stirrer, condenser, addition funnel, thermometer, vacuum, inert gas, sampling, pH probe), stirrer (overhead stirrer with PTFE or 316L shaft; blade type (anchor, paddle, turbine, PTFE); speed range (50-2000 RPM); explosion-proof motor (ATEX) for flammable solvents), temperature control (ambient to 200-250 degrees C heating; -20 to -80 degrees C cooling (with chiller); precision +/- 0.1-0.5 degrees C; digital controller with PID, ramp/soak programming), pressure/vacuum (full vacuum to slight positive pressure (typically -1 to +0.5 bar); do not exceed glass rating; for higher pressure use metal autoclave), materials (borosilicate glass 3.3 vessel; PTFE seals/stirrers (chemical resistance); 316L stainless steel (for parts); silicone/Viton gaskets), accessories (reflux condenser, addition funnel (pressure-equalizing), distillation head, receiver flask, vacuum pump, heating/cooling circulator (oil/water), chiller, inert gas (N2/Ar) setup, pH probe, data logging/software, explosion-proof (ATEX) for hazardous areas, validation package (IQ/OQ/PQ for pharma), certifications (CE, ISO, FDA food contact, ATEX), language and accessories. Additional glassware, circulator, and accessories can be ordered separately.
Q9: Does the purchase include on-site installation and commissioning service?
A: Standard delivery includes jacketed glass reactor (vessel, lid, stirrer, basic accessories), stand, temperature controller, and instruction manual. On-site installation, commissioning, and operator training ARE typically included or strongly recommended for jacketed glass reactors (glass assembly requires proper setup (clamping, alignment, seal installation), heating/cooling circulator integration, leak testing, and user training on safe operation (thermal shock, pressure/vacuum, chemical handling); installation by manufacturer or certified technician is standard, especially for >10 L or automated systems). For small lab reactors (1-5 L): self-assembly is possible with manual guidance, but initial training on safe operation is recommended. Always inspect glass for damage, test for leaks, and verify temperature/stirrer before first use.
Q10: What types of samples are compatible with this equipment?
A: The jacketed glass reactor handles various chemical reactions and materials including organic chemicals (solvents, reagents, monomers, polymers - synthesis, polymerization, distillation, crystallization), pharmaceutical intermediates and APIs (synthesis, crystallization, salt formation, solvent recovery), food-grade ingredients (flavors, fragrances, essential oils, extracts, sugars - distillation, extraction, reaction; use food-grade materials), cosmetics/personal care (emulsions, creams, surfactants, fragrances), and aqueous/organic solutions. Glass (borosilicate 3.3) is compatible with most acids, bases, solvents, and organic compounds. NOT compatible with: Hydrofluoric acid (HF) - etches/attacks glass (use PTFE or plastic vessels), strong bases (NaOH, KOH) at high temperature (>100 degrees C) and high concentration - etches borosilicate over time (use PTFE-lined or limit exposure), very high pressure (>0.5-1 bar positive pressure) - glass is not rated for high pressure (use metal autoclave), extremely rapid temperature changes (thermal shock cracks glass - heat/cool gradually), dry heating (jacket must have circulating fluid when heating; dry heat cracks glass), samples that foam/boil over (do not overfill; use anti-foam, larger vessel, controlled heating), highly exothermic reactions without proper cooling/capacity (can runaway - ensure circulator capacity and controlled addition), and materials that attack PTFE/stirrers (some molten alkali metals, certain fluorinated compounds at high temp - verify compatibility). Also not for: high-temperature molten metals/salts (>250 degrees C, beyond glass/circulator rating), reactions requiring high pressure (use autoclave), and large-scale production (>200 L, use pilot plant glass-lined steel reactors). IMPORTANT: Jacketed glass reactor fundamentals: (1) What it is: A double-walled (jacketed) borosilicate glass vessel used for controlled chemical reactions. The inner vessel holds the reaction mixture; the outer jacket circulates a heat transfer fluid (thermal oil for heating, water/glycol for cooling) to control temperature. Transparent glass allows visual monitoring. Overhead stirrer mixes contents. Various ports allow reagent addition, temperature measurement, condensation, vacuum/inert gas. (2) Key components: - Jacketed vessel: Borosilicate glass 3.3 (chemical resistance, thermal shock resistance, transparent). Inner volume 1-200 L. - Jacket: Circulates heating/cooling fluid. Inlet/outlet ports. Must always have fluid when heating/cooling. - Lid: Multi-neck (4-6 ports) for stirrer, condenser, addition, thermometer, vacuum, gas. - Overhead stirrer: Motor + shaft + blade (PTFE or 316L). Mixes reaction. Speed 50-2000 RPM. - Temperature probe: Thermowell or direct probe. Measures reaction temp. - Condenser: Reflux (returns vapors) or distillation (collects distillate). - Addition funnel: Controlled reagent addition (pressure-equalizing for closed systems). - Vacuum/gas ports: For vacuum distillation, degassing, inert atmosphere (N2/Ar). - Stand: Supports glass vessel (floor or bench). - Heating/cooling circulator: Provides fluid at set temp to jacket (separate equipment). (3) Temperature control: - Heating: Thermal oil (up to 200-250 degrees C) or water (up to 100 C). - Cooling: Water (to ~10 C), ethylene glycol/water (to -20 C), or chiller (to -80 C). - The jacket circulates fluid, controlling vessel wall temp, which controls reaction temp. - Precision: +/- 0.1-0.5 degrees C with PID controller. - Heat/cool GRADUALLY to avoid thermal shock (major cause of glass breakage). (4) Pressure/vacuum: - Typically designed for full vacuum (for distillation, degassing, removing solvents) to slight positive pressure. - NEVER exceed manufacturer pressure rating (glass can explode). - For pressure reactions, use metal autoclave (not glass). - Under vacuum, beware of IMPLOSION (glass shatters inward, flying debris) - use blast shield, face shield. (5) Common reactions/applications: - Organic synthesis (condensation, oxidation, reduction, polymerization, Grignard, etc.) - Crystallization (controlled cooling, seeding) - Distillation (simple, fractional, vacuum, steam) - Reflux (heating with condenser to retain volatile solvent) - Extraction (liquid-liquid, solid-liquid) - Emulsion/cream preparation (cosmetics, pharma) - Fermentation/bioconversion (if temp controlled, sterile) - Process scale-up (lab 1L -> pilot 50-100L) (6) Safety (critical for glass reactors): - Thermal shock: #1 cause of breakage. Never put cold coolant in hot jacket or hot fluid in cold vessel. Heat/cool gradually (<5 degrees C/min). - Glass breakage: Inspect before each use (cracks, stars). Do not use damaged glass. Support properly (no stress on joints). - Pressure/vacuum: Never exceed rating. Use blast shield. Under vacuum = implosion risk. - Chemical compatibility: HF attacks glass. Hot strong bases etch glass. Verify all materials (glass, PTFE, seals) with chemicals. - Overfilling: Max 2/3 volume (boiling/foaming). - Exothermic reactions: Can runaway. Use cooling, controlled addition, monitoring. Never leave unattended. - Flammable solvents: Use fume hood, spark-free (explosion-proof) stirrer, no open flame, inert atmosphere. - Stirrer: Do not let blade touch glass (scratches/cracks). Start at low speed. - Cleaning: Do not use abrasive brushes (scratches weaken glass). Rinse with solvent then water. Dry thoroughly. (7) Jacketed vs non-jacketed: - Jacketed: Precise temp control via circulating fluid, faster heating/cooling, can heat and cool. For controlled reactions. - Non-jacketed (single wall): Heated via heating mantle or oil bath. Less precise, slower. Simple, cheaper. - For process development and scale-up, jacketed is preferred. (8) Choosing the right reactor: - Volume: 1-5 L for lab research, 10-50 L for pilot, 100-200 L for scale-up. - Temp range: Ambient to 200 C standard; low temp (-80 C) needs chiller. - Pressure: Atmospheric/vacuum standard; high pressure needs autoclave. - Automation: Manual (basic) vs automated (software, data logging, recipe control) for GMP/scale-up. - Hazardous location: Explosion-proof (ATEX) for flammable solvents. - Material: Borosilicate glass standard; PTFE-lined for HF/bases.
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