Introduction
Liquid chromatography mass spectrometry (LC-MS) is an analytical technique that combines the separation of the liquid chromatography with the detection and the identification of the mass spectrometry, and it is used in the pharmaceutical, the biotechnology, the clinical, the food, the environmental, and the many other applications. In the LC-MS, the sample is separated by the liquid chromatography (LC), and the separated compounds are introduced into the mass spectrometer, in which the compounds are ionized, separated by the mass-to-charge ratio, and detected, and the technique provides the high sensitivity and the selectivity for the identification and the quantification of the compounds; the LC-MS system consists of a liquid chromatograph, an interface with the ionization source, such as the electrospray ionization (ESI) or the atmospheric pressure chemical ionization (APCI), a mass analyzer, such as the quadrupole or the time-of-flight, a detector, and the data system, and it is used for the analysis of the drugs and the metabolites, for the analysis of the biomolecules, for the analysis of the contaminants and the residues, for the proteomics and the metabolomics, for the quality control, and for many other applications, with features such as the high sensitivity and the accurate mass; the LC-MS is an essential analytical technique in the modern laboratories. LC-MS systems are used in the pharmaceutical industry, in the clinical laboratories, in the food and the environmental analysis, in the research institutions, and for many other applications. With their combination, LC-MS systems are essential for the sensitive and the selective analysis.
Liquid Chromatography - Mass Spectroscopy T-S210LMS
Liquid Chromatography - Mass Spectroscopy is table top unit with the hyphenated combination of liquid chromatography and mass spectroscopy for chemical separation and identification of or...
Standards
USP General Chapter <621>-Chromatography
European Pharmacopoeia 2.2.46-Chromatographic separation techniques
WHO TRS 1025 Annex 4-Good chromatography practices
Complies with the above standards, but is not limited to them.
Features
1. Combines high-performance liquid chromatography separation with mass spectrometry detection for complex mixture analysis.
2. Supports qualitative identification and quantitative measurement of compounds in biological, environmental and chemical samples.
3. Available with electrospray and atmospheric pressure chemical ionization sources for broad compound coverage.
4. Software supports mass spectral library searching, quantitation workflows and regulatory-compliant data management.
5. Requires trained operators and dedicated laboratory space with proper ventilation and power conditioning.
FAQ
Q1: What testing scenarios is this instrument mainly applied to?
A: LC-MS systems are used for trace-level analysis in pharmaceutical impurity profiling, clinical toxicology, environmental contaminant monitoring, food safety testing and metabolomics research. They support compound identification, structure confirmation and quantitation in complex matrices where chromatography alone cannot resolve all components and where high sensitivity and selectivity are required.
Q2: What standards does the instrument comply with?
A: The system supports analytical methods referenced in USP, EP and ChP monographs, ISO 17025 for testing laboratory competence, and relevant ASTM and GB/T methods for specific analytes. The instrument hardware complies with IEC 61010 laboratory safety standards. Electronic records may be configured for 21 CFR Part 11 compliance.
Q3: What is the warranty period for the whole machine and key components?
A: Standard warranty is 12 months from commissioning. The mass analyzer, detector, pumps and control system are covered, while columns, solvents, sample vials and ion source components are consumables excluded from warranty. Extended warranty and service contracts are available for this high-value system.
Q4: Is this device difficult to operate? Is professional training required?
A: LC-MS operation requires specialist training in chromatography, mass spectrometry and method development. We provide structured operator training, application support and method consultation. Routine use by trained analysts is supported by software wizards and standard operating procedures.
Q5: What is the typical lead-time for order delivery?
A: Standard models require 7-30 working days. In-stock units can ship within 3-7 working days. Custom configurations or large built-to-order systems may require additional time, and we confirm the exact schedule before order confirmation.
Q6: Is regular calibration required? What is the recommended calibration cycle?
A: Mass calibration and resolution verification should be performed according to the manufacturer schedule, typically monthly or per analytical batch for quantitative work. System suitability testing with reference standards before each batch is required for regulated methods. Annual preventive maintenance by a certified engineer is strongly recommended.
Q7: Are supporting consumables universal? What about the long-term procurement cost?
A: LC columns, solvents, sample vials and calibration standards are available from multiple qualified suppliers, though original columns and ion source parts are recommended for optimal performance. Long-term consumable and service cost is significant and should be included in the annual laboratory budget for this system.
Q8: Can I customize parameters or supporting accessories?
A: Customization includes ionization source configuration, mass range, detector type, autosampler capacity and software modules. Custom orders require detailed application discussion and extend lead-time. Users should define target analytes, matrices and sensitivity requirements before configuration.
Q9: Does the purchase include on-site installation and commissioning service?
A: Yes, LC-MS systems include on-site installation, commissioning and operator training by a certified application specialist. Site preparation guidance is provided before delivery to ensure the laboratory meets power, ventilation and environmental requirements.
Q10: What types of samples are compatible with this equipment?
A: The system analyzes liquid-soluble organic and some inorganic compounds within the mass range and ionization capability. Samples must be filtered and free of particulate matter to protect the column and ion source. Highly saline, strongly acidic or basic samples may require dilution or special pretreatment to avoid source contamination and signal suppression.
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