Tissue homogenizer

Introduction

A tissue homogenizer is a laboratory instrument used to disrupt and homogenize biological tissues and cells into a uniform suspension or homogenate, and it is used in biochemistry, molecular biology, and research laboratories for preparing tissue samples for protein, nucleic acid, and enzyme analysis. The homogenizer breaks the tissue and cells by mechanical, physical, or other means, and various types are available, including the rotor-stator homogenizer, which uses a rapidly rotating blade or rotor inside a stator to shear the tissue; the bead mill homogenizer, which uses grinding beads shaken at high speed with the sample to disrupt the cells; the ultrasonic homogenizer, which uses ultrasonic cavitation; the Dounce and Potter-Elvehjem homogenizers, which use a pestle; and the pressure homogenizer, and the choice depends on the tissue type and the application, and the homogenate is then used for the extraction of proteins, DNA, RNA, and other components, for enzyme assays, and for other analyses. Tissue homogenizers are used for homogenizing animal tissues, such as liver, brain, kidney, and muscle, for homogenizing plant tissues, for disrupting cells and bacteria, for preparing samples for protein and nucleic acid extraction, for preparing homogenates for enzyme assays, for drug metabolism studies, for food analysis, and for many other applications, and they are available in various configurations, from small handheld models to large benchtop instruments, with features such as adjustable speed, temperature control, and different processing volumes. With their effective tissue disruption, tissue homogenizers are essential for sample preparation in biological research.

Tissue Homogenizer LATH-T2012

Tissue Homogenizer achieve powerful sample processing with frequency of 30Hz to 70Hz, ensuring thorough and effective results. Feature high-powered motors, ensuring consistent specimen p...

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Tissue Homogenizer LATH-T2011

Tissue Homogenizer provides both wet and dry grinding options, operating at speeds ranging from 2450 to 4450 rpm. It employs three-dimensional movement for effective and smooth grinding ...

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Tissue Homogenizer LATH-T2010

Tissue Homogenizer Can process up to 192 samples simultaneously within 1 minute. It provides a wide range of homogenization speed from 0 to 70 Hz. The homogenizer offers independent cool...

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Standards

IEC 61010-2-051:2018-Particular requirements for laboratory equipment for mixing and stirring

Complies with the above standards, but is not limited to them.

Features

1. Tissue homogenizer for mechanical disruption and homogenization of biological tissues.

2. Rotary blade or probe-type homogenization for sample preparation in biological research.

3. Suitable for molecular biology, biochemistry, clinical, pharmaceutical and research labs.

4. Includes homogenizer probe/unit, sample tubes, controller, stand and operation manual.

5. Supports tissue disruption for DNA/RNA/protein extraction and sample preparation.

FAQ

Q1: What testing scenarios is this homogenizer mainly applied to?

A: The tissue homogenizer is used in molecular biology, biochemistry, clinical diagnostics, pharmaceutical research, biotechnology, forensics and research to mechanically disrupt and homogenize biological tissues (animal, plant, human) for sample preparation prior to DNA, RNA, protein extraction and other analytical procedures. It supports molecular biology sample preparation (tissue disruption for DNA/RNA/protein extraction), clinical diagnostic sample processing, pharmaceutical research tissue analysis, biotechnology sample preparation, forensic sample processing, plant tissue homogenization, and general biological sample preparation. The mechanical homogenization efficiently disrupts tough tissue structures (muscle, liver, brain, plant) to release intracellular contents, supporting efficient extraction of nucleic acids, proteins and other biomolecules for downstream analysis.

Q2: What standards does the homogenizer comply with?

A: The tissue homogenizer follows relevant ISO, ASTM and GB/T standards for laboratory equipment, including IEC 61010 laboratory electrical safety standards, IEC 61326 EMC standards, and applicable GB/T standards for laboratory homogenizers. The hardware complies with applicable safety standards. For clinical/pharmaceutical use, follow applicable GMP/GLP and data integrity requirements. Users should verify compliance with specific facility requirements. Sample handling follows applicable biosafety regulations.

Q3: What is the warranty period for the whole homogenizer and key components?

A: The whole tissue homogenizer is covered by a 12-month warranty. The motor, drive shaft, probe/blade, controller, stand and housing are covered, while probes, blades, sample tubes, seals and fuses are consumables or accessories. Damage from improper use, overloading, probe damage or unauthorized repair is excluded. Extended service contracts may be available.

Q4: Is this device difficult to operate? Is professional training required?

A: Operation requires trained laboratory personnel familiar with tissue homogenization, sample preparation and biosafety. We provide operation manuals, training and application support. Proper sample preparation (tissue size, buffer ratio), probe selection, homogenization technique (speed, time, cooling), cleaning (cross-contamination prevention), biosafety procedures and result assessment are important for effective, reproducible tissue homogenization.

Q5: What is the typical lead-time for order delivery?

A: Standard models require 7-30 working days. In-stock units can ship within 3-7 working days. Custom configurations or large built-to-order systems may require additional time, and we confirm the exact schedule before order confirmation.

Q6: Is regular calibration required? What is the recommended calibration cycle?

A: Speed calibration recommended every 6-12 months for critical applications. Probe/blade condition checked (wear, damage). Routine cleaning and maintenance. Full homogenizer performance verification annually. Motor and drive system checked per schedule. Seals and gaskets inspected regularly.

Q7: Are supporting consumables universal?

A: Probes, blades, sample tubes, seals, cleaning supplies and fuses are available from laboratory suppliers, though probe type should match the homogenizer. Long-term consumable cost depends on usage and probe wear.

Q8: Can I customize parameters or supporting accessories?

A: Customization includes homogenizer type (rotary blade, probe-type/ultrasonic, bead mill), speed range, probe size, sample capacity, stand type, timer, data output and accessories. Additional probes, blades, stands and accessories can be ordered separately. Custom orders extend delivery lead-time.

Q9: Does the purchase include on-site installation and commissioning service?

A: No complex installation is required for portable tissue homogenizers. The package includes the homogenizer, probe, stand and instruction manual. On-site training is available at additional cost for laboratory setup.

Q10: What types of samples are compatible with this equipment?

A: The tissue homogenizer disrupts animal tissues (muscle, liver, brain, kidney, heart), plant tissues (leaves, stems, roots), human clinical specimens, cell pellets and other biological materials within the sample size, tissue type and probe specification. Different tissue types require specific homogenization conditions: soft tissues (liver, brain) require less force/time; tough tissues (muscle, skin, plant) require more force/time or pre-cutting. Very fibrous or hard tissues may require bead milling or enzymatic pretreatment. Users should select appropriate probe size for the sample volume, cut tissue into small pieces (typically <5 mm) for efficient homogenization, use appropriate buffer ratio (typically 5-10 volumes buffer per tissue weight), keep samples cold (on ice or use cooling jacket) to prevent protein degradation/nucleic acid shearing, homogenize with proper speed and time (avoid over-homogenization which can cause excessive heating and nucleic acid shearing), clean probe thoroughly between samples (to prevent cross-contamination - use RNAse/DNAse-free conditions for nucleic acid work), follow proper biosafety procedures (human/animal tissues may contain pathogens), and for downstream extraction, follow proper protocol (DNA, RNA, protein extraction kits). The homogenizer should be placed on a stable surface. The probe should be inspected regularly for wear (worn blades reduce efficiency). For nucleic acid extraction, use RNase/DNase-free conditions and avoid over-homogenization (can shear high-molecular-weight DNA). For protein extraction, use protease inhibitors and keep samples cold. For tough tissues, consider enzymatic pretreatment (proteinase K) or bead milling. The homogenizer should be cleaned immediately after use (tissue residue can dry and harden, making cleaning difficult). For clinical samples, follow proper biosafety (BSL-2 for human tissues) and waste disposal regulations. The homogenizer should not be used for samples that are too large or too hard for the probe (can damage the motor or probe).