Introduction
An Ames test system is a system used for the Ames test, which is a bacterial reverse mutation assay for the detection of the mutagenic potential of the substances, and it is used in the toxicology, the pharmaceutical, the chemical, and the research institutions. The Ames test uses the specific strains of the bacteria, such as the Salmonella typhimurium, which are exposed to the test substance, and the mutagenic substances cause the reverse mutations, which are detected by the growth of the colonies on the selective media, and the Ames test system provides the materials and the equipment for the test, including the bacterial strains, the media, the reagents, and the incubators; the Ames test system is used for the screening of the mutagenic potential of the chemicals, the pharmaceuticals, the environmental samples, and the food additives, for the genotoxicity testing, for the regulatory testing, for the research, and for many other applications, and it is an essential system for the genetic toxicology. Ames test systems are used in the toxicology laboratories, in the pharmaceutical industry, in the chemical industry, in the research institutions, and for many other applications. With their bacterial reverse mutation assay, Ames test systems are essential for the mutagenicity testing.
Automatic Ames Test System T-S2AT-S2100
Standards
OECD Test Guidelines-genetic toxicology (bacterial reverse mutation / Ames) and inhalation toxicity studies
Complies with the above standards, but is not limited to them.
Features
1. Ames test system for bacterial reverse mutation assay in genotoxicity testing.
2. Automated or semi-automated platform for plating, incubation and colony counting.
3. Suitable for pharmaceutical, chemical, cosmetic and regulatory genotoxicity screening.
4. Includes incubator, colony counter, software and standard tester strains.
5. Supports GLP-compliant mutagenicity testing for regulatory submissions.
FAQ
Q1: What testing scenarios is this system mainly applied to?
A: The Ames test system is used in pharmaceutical toxicology, chemical safety assessment, cosmetic ingredient testing, environmental mutagenesis research and regulatory testing laboratories to perform the bacterial reverse mutation assay (Ames test) for detecting mutagenic potential of chemicals, drugs, cosmetics and environmental agents. It supports preclinical drug development genotoxicity screening, chemical registration requirements, cosmetic ingredient safety evaluation, environmental pollutant mutagenicity assessment and academic research. The Ames test is a core component of the standard genotoxicity test battery required by regulatory agencies including FDA, EPA and OECD. The automated system improves throughput, reduces manual counting variability and supports GLP-compliant data management for studies required for drug approval, chemical registration and product safety evaluation worldwide.
Q2: What standards does the system comply with?
A: The assay follows OECD Test Guideline 471 for bacterial reverse mutation test, FDA and EPA genotoxicity guidelines, and ICH S2(R1) for genotoxicity testing of pharmaceuticals. The system supports GLP good laboratory practice compliance. Tester strains include Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2 uvrA as specified in the guideline.
Q3: What is the warranty period for the whole machine and key components?
A: The whole system is covered by a 12-month warranty. The incubator, colony counter, software and controller are covered, while culture media, plates and reagents are consumables excluded from warranty. Damage from improper use or unauthorized repair is excluded. Extended service contracts are available.
Q4: Is this device difficult to operate? Is professional training required?
A: Operation requires trained microbiology and toxicology personnel familiar with the Ames assay and GLP procedures. We provide structured training, operation manuals and application support. Proper strain maintenance, metabolic activation preparation, plating technique and colony counting are critical for valid results.
Q5: What is the typical lead-time for order delivery?
A: Standard models require 7-30 working days. In-stock units can ship within 3-7 working days. Custom configurations or large built-to-order systems may require additional time, and we confirm the exact schedule before order confirmation.
Q6: Is regular calibration required? What is the recommended calibration cycle?
A: Colony counter calibration with reference plates is recommended annually or per GLP requirements. Incubator temperature calibration every 6-12 months. Software validation follows the manufacturer schedule and GLP change control. Tester strain genotype verification should be performed periodically according to the guideline.
Q7: Are supporting consumables universal?
A: Culture media, agar plates, reagents and tester strains are available from multiple diagnostic and research suppliers, though quality should meet assay requirements. Long-term consumable cost depends on testing volume and includes media, reagents and biological materials.
Q8: Can I customize parameters or supporting accessories?
A: Customization includes automation level, incubation capacity, counting configuration and software features. Additional accessories and reagent sets can be ordered separately. Custom orders extend delivery lead-time.
Q9: Does the purchase include on-site installation and commissioning service?
A: Yes, Ames test systems include on-site installation, commissioning, validation and operator training by certified application specialists. Site preparation guidance is provided before delivery to ensure incubator space, power and biosafety requirements are met.
Q10: What types of samples and applications are compatible with this equipment?
A: The system tests chemicals, drugs, cosmetics, environmental samples and mixtures for mutagenic potential using bacterial tester strains. Volatile, gaseous or highly toxic test articles may require modified protocols or special containment. Users should follow OECD 471 procedures including appropriate tester strains, metabolic activation, dose selection and positive/negative controls. All regulatory studies should be conducted under GLP with proper documentation, strain verification and data integrity controls.
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