Liquid Chromatography Mass Spectrometry LCMS-T2011

Introduction

Liquid Chromatography Mass Spectrometry features a flow rate range of 1 to 4000 µL/min, adjustable in 1.0 µL/min steps for precise control. It uses a triple quadrupole tandem mass spectrometer for accurate analysis. The system supports full loop, semi-loop, and microliter injection modes to suit various sample needs. It is equipped with advanced E Spray biorthogonal electrospray ion source technology, offering high ionic yield and strong resistance to matrix effects. Our liquid chromatography mass spectrometry delivers high sensitivity in detecting sulfonamides in pork, pesticides in water, environmental pollutants, neonatal diseases, and vitamin D in serum.

This analytical equipment is designed to meet the rigorous requirements of modern laboratory operations, ensuring high precision, reliability, and ease of use for various experimental applications.

Applications

Liquid Chromatography Mass Spectrometry detects sulfonamides in pork, pesticides in water, pollutants, neonatal diseases, and vitamin D levels in serum with high sensitivity.

Specifications

Flow Range	1 to 4000 µL/min, increments of 1.0 µL/min
Accuracy of Flow Rate	≤1%
Precision of Flow Rate	≤0.07%
Maximum Pressure	≥18000 psi
Mobile Phase Selection	Solvent selection valve allows any two of A, B, C, D as mobile phase
Vacuum Degasser	Built-in; each pump degassed separately (A / B)
Delay Volume	<50 µL (includes 35 µL mixer)
Gradient Modes	Linear, concave, convex
Gradient Range	0 to 100%
Gradient Precision	≤0.15%
Gradient Accuracy	±0.5% (absolute), 5% to 95%
Pressure Fluctuation	<1% of system pressure or 5 bar (whichever greater)
Injection Modes	Full loop, semi-loop, microliter
Injection Repeatability	Full: <0.3% ; Semi: <0.5% ; Micro: <1.0%
Sample Capacity	Max 384 positions; ≥96 positions for 2 mL vials
Injection Range	1–500 µL (standard); 250, 1000, 2500 µL (optional)
Residue	<0.05% (standard); <0.01% (extra rinse);
Sample Cooling	4℃±2℃ (min); Room temp to -3℃(max)
Temperature Control Range	Room temp +5℃ to 90℃
Temperature Control Method	Mobile phase preheating + forced air circulation
Maximum Column Capacity	≥5 columns, length ≥250 mm
Design	Orthogonal vertical spray, anti-pollution, low background noise
Ion Source Gases	1 atomizing + 2 desolvation gases; flow rate set in software
Spray Voltage	Max 6 kV; settable in software
Aux Heating Temp	≥700℃; settable in software
Exhaust Device	Prevents backflow, reduces memory effect, protects pump and environment
Ion Interface	Cone hole or capillary; capillary design requires 50 extra capillaries
Back-Blowing Design	Reduces neutral molecule introduction
Interface Temp	≥110℃ to improve anti-pollution
Ion Transmission System	4-stage differential vacuum with multi-quadrupole focusing
Mass Analyzer	Triple quadrupole
Quadrupole Material	High-precision pure Mo; no need for extra temp control
Quadrupole Surface	Gold-plated for anti-contamination
Quadrupole Structure	Pre-rods before/after first; front pre-rod in second quadrupole
Collision Cell	Linear or 90° curved; curved requires 3 years free cleaning commitment
Collision Gas	High-purity nitrogen
Sensitivity	+: 1 pg reserpine, S/N≥300,000:1; -: 1 pg chloramphenicol, S/N≥300,000:1
Quantitative Reproducibility	Reserpine & Chloramphenicol: ≤5% (6 injections)
Quadrupole Resolution	0.4 to 3.0 amu adjustable
Mass Stability	≤0.1 amu/24h
Scan Speed	≥20,000 amu/s
Min Scan Step	0.02 amu
Dynamic Range	6 orders of magnitude
Channels	≥30,000 groups per injection with no sensitivity loss
Min Dwell Time	1 ms
MS/MS Switch Time	≤1 s
Detector Type	Electron multiplier tube
Detection Method	Pulse counting for low concentration reproducibility
Vacuum System Configuration	Mechanical + turbomolecular pump, differential exhaust, auto power-off
Mechanical Pump Speed	65 m³/h
Turbo Pump Speed	50 / 400 / 500 L/s
Workstation Software Platform	Windows XP and above
Automation	Calibration, instrument monitoring
Power Supply	(220±20) V AC，10A，50 Hz
Dimension	750 × 660 × 670 mm
Packaging Dimension	940 × 830 × 600 mm
Net Weight	48 Kg
Gross Weight	68 Kg

Features

Step scan ion transmission

Low-noise pulse counting detection

Superior stability

High sensitivity

User-friendly design

FAQs

1. What is It Liquid Chromatography Mass Spectrometry used for in laboratories?

It Liquid Chromatography Mass Spectrometry is widely used for detecting and analyzing trace amounts of substances in complex samples. It plays a crucial role in food safety, environmental monitoring, clinical diagnostics, and pharmaceutical research. For example, it can detect sulfonamides in pork, pesticides in water, pollutants in soil, and even vitamin D levels in blood serum. Its high sensitivity and accuracy make it ideal for identifying very small quantities of chemicals, which is essential for quality control and public health safety.

2. How does Liquid Chromatography Mass Spectrometry system ensure accurate and sensitive results?

It system combines high-performance liquid chromatography with a triple quadrupole mass spectrometer to achieve exceptional precision. The use of advanced technologies like step scan ion transmission, low-noise pulse counting detection, and a gold-plated quadrupole structure ensures minimal background interference and high signal clarity. Additionally, its E Spray biorthogonal electrospray ion source provides strong resistance to matrix effects, which helps maintain consistent accuracy even when analyzing complex or dirty samples.

3. What makes It Liquid Chromatography Mass Spectrometry suitable for various sample types and injection methods?

It system is designed for flexibility, allowing users to choose from full loop, semi-loop, or microliter injection modes based on the sample type and volume. It supports a wide range of flow rates and has a highly accurate and repeatable injection system, ensuring reliable results with minimal sample residue. This makes it suitable for both routine laboratory testing and advanced research where different injection techniques may be needed depending on the sample’s characteristics.

4. How does It Liquid Chromatography Mass Spectrometry maintain system stability and performance over time?

It uses a robust design with a four-stage differential vacuum and multi-quadrupole focusing for stable ion transmission. It also features a vacuum system with both mechanical and turbomolecular pumps, ensuring consistent pressure and protection against backflow. Features like preheated mobile phase lines, anti-pollution spray design, and gold-plated components reduce contamination risks and extend maintenance intervals. These aspects ensure the instrument remains stable and reliable even during long-term, high-throughput operations.

5. Can It Liquid Chromatography Mass Spectrometry be used in regulated or clinical environments?

Yes, It Liquid Chromatography Mass Spectrometry is suitable for use in regulated environments, including clinical laboratories. Its automation features such as built-in calibration, instrument monitoring, and temperature control support compliance with strict quality standards. The system is designed for high-throughput applications with excellent reproducibility, making it reliable for diagnosing neonatal diseases or monitoring therapeutic drug levels. Its ability to detect extremely low concentrations with high precision is particularly important in clinical and pharmaceutical settings.